High-sensitivity troponin assays are the preferred biomarker for the detection of myocardial injury. Levels are reported in ng/L. The assay-specific 99th percentile upper reference limit is the threshold for the diagnosis of myocardial injury.
The benefits of hs-cTn assays are that they expedite the evaluation of patients with suspected acute coronary syndrome through early identification of low-risk patients eligible for early discharge.
The 99th percentile upper reference limit of hs-cTn assays is derived from samples of male and female participants presumed healthy through screening.
The 99th percentile upper reference limit is sex-specific, with women typically having lower 99th percentiles than men. The impact of using sex-specific reference limits on outcomes is unclear.
The limit of detection of an hs-cTn assay is the lowest concentration of the analyte that can be detected. The limit of quantitation (LoQ) is the lower concentration of the analyte of which certainty can be quantified (i.e., with a coefficient of variation of 20%).
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