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- How it works. Bupropion is an antidepressant that may also be used to help people quit smoking. Experts do not know exactly how bupropion works in depression but historically it was thought to be due to its ability to inhibit the reuptake of two neurotransmitters, norepinephrine, and dopamine (although this reuptake inhibition is weak).
- Upsides. Bupropion (Wellbutrin [discontinued], Aplenzin, and generic bupropion) may be used to relieve the symptoms of depression in Major Depressive Disorder (MDD) and Seasonal Affective Disorder (SAD).
- Downsides. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include
- Bottom Line. Bupropion may be used in the treatment of depression or as an aid to smoking cessation; however, side effects may include insomnia, neuropsychiatric adverse events, or seizures.
- Tips. Can be taken with or without food. Avoid taking the last dose of the day after 5pm to minimize the risk of insomnia. At least eight hours should separate twice daily dosings of bupropion, and at least six hours should separate three times daily dosings of bupropion.
- Response and effectiveness. When bupropion is used for depression, improvements in sleep, energy, or appetite may be apparent within the first 1-2 weeks.
- Interactions. Medicines that interact with bupropion may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with bupropion.
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