RCSB PDB - 7UB0: SARS-COV-2 OMICRON-BA.2 3-RBD DOWN …
Mar 14, 2022 BA.2 receptor-binding domain (RBD) mutations induce remodeling of the RBD structure, resulting in tighter packing and improved thermostability. Interprotomer RBD interactions are enhanced in the closed (or 3-RBD-down) BA.2 S, while the fusion peptide is less accessible to antibodies than in BA.1. From rcsb.org
RCSB PDB - 8ZES: CRYSTAL STRUCTURE OF THE WUHAN SARS-COV-2 …
May 6, 2024 Here we report on the successful crystal structure determination of the RBD:P2C5 complex at 3.1 Å, which revealed the intricate protein-protein interface, sterically occluding full ACE2 receptor binding by the P2C5-neutralized RBD. From rcsb.org
RCSB PDB - 8IDN: CRYO-EM STRUCTURE OF RBD/E77-FAB COMPLEX
Feb 13, 2023 Antibodies that target the receptor-binding domain (RBD) of S have high potency in preventing viral infection. The ongoing evolution of SARS-CoV-2, especially mutations occurring in the RBD of new variants, has severely challenged the development of neutralizing antibodies and vaccines. From rcsb.org
Aug 1, 2005 A defined receptor-binding domain (RBD) on S mediates this interaction. The crystal structure at 2.9 angstrom resolution of the RBD bound with the peptidase domain of human ACE2 shows that the RBD presents a gently concave surface, which cradles the … From rcsb.org
Spike protein from SARS-CoV, with one receptor binding domain (RBD) in the up position, and a closed conformation of the SARS-CoV-2 spike. The S1 fragment is shown in magenta and the S2 fragment in red, with glycosylation in lighter shades. From pdb101.rcsb.org
CRYSTAL STRUCTURE OF SARS-COV-2 SPIKE RECEPTOR-BINDING
Feb 21, 2020 Here, to better understand the initial step of infection at an atomic level, we determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 bound to the cell receptor ACE2. From rcsb.org
RCSB PDB - 8ZER: CRYSTAL STRUCTURE OF THE COMPLEX OF WUHAN …
May 6, 2024 Here we report on the successful crystal structure determination of the RBD:P2C5 complex at 3.1 Å, which revealed the intricate protein-protein interface, sterically occluding full ACE2 receptor binding by the P2C5-neutralized RBD. From rcsb.org
RCSB PDB - 7L4Z: STRUCTURE OF SARS-COV-2 SPIKE RBD IN …
Dec 21, 2020 Here, we describe the affinity selection of cyclic peptide ligands to the SARS-CoV-2 spike protein receptor binding domain (RBD) from three distinct libraries (in excess of a trillion molecules each) by mRNA display. From rcsb.org
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from … From rcsb.org
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