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How it works. Hydralazine is a vasodilator - this means it relaxes smooth muscle inside blood vessels, making the blood vessels wider, and allowing more blood to flow through.
Upsides. May be used for the treatment of high blood pressure (BP), either alone or in combination with other agents. May be given in combination with isosorbide dinitrate to treat heart failure in self-identified black patients in addition to standard therapies to improve survival, decrease hospitalization rates, and improve patient well-being.
Downsides. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include
Bottom Line. Hydralazine lowers blood pressure (BP) but also stimulates the heart which may increase the heart rate and lead to angina symptoms. It is not a preferred agent for BP-lowering but may be used in addition to other recommended treatments in people whose BP is hard to control.
Tips. May be taken with or without food, but should be taken consistently either with or without food. Food may increase the blood levels of hydralazine, increasing the risk of side effects such as a blood pressure drop when standing.
Response and effectiveness. Peak blood levels of hydralazine are usually reached one to two hours after oral hydralazine; sooner if injectable hydralazine is used.
Interactions. Medicines that interact with hydralazine may either decrease its effect, affect how long it works for, increase side effects, or have less of an effect when taken with hydralazine.
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